The Beaming technology can be used to detect mutations present in cancerous cells without the need for a physical biopsy. This technology can be used to detect mutations in circulating tumor DNA (ctDNA), which can be found at very low concentrations in peripheral blood samples. Using this type of analysis, researchers and clinicians can obtain vital information about cancer initiation, development, metastasis and response to therapy without the need for invasive surgery. The Beaming module manages and tracks the samples analyzed using this technology. The following activities are available.
The user plans a set of aliquots for experiment using the Beaming technology from the Biobank module. During the experiment planning the user defines also a title and description (optional). Before performing the molecular experiment, the user should validate the scheduled aliquots and confirm the used quantity for each aliquot. The user should insert the barcode of each aliquot to perform the validation procedure.
All validated requests are visualized. After selecting an experiment, the user should define the instrument and the layout of the support used in the experiment. Once these parameters have been defined, the system shows the samples from the selected experiment and the layout of the support. The mutation targets used by the user in other experiments are shown in the “Targets” table. It is possible to add new targets by performing a search according to the gene symbol and/or the mutation syntax. The samples and the targets can be associated with the positions of the support by clicking on a single cell or the column/row header. The positions of the support will be updated with the sample label and/or target color. A position may contain only one sample and one target. Only the positions containing both a sample and a target will be saved into the system.
All experiments for which a layout has been defined are visualized. By selecting an experiment, the user can upload a file with the liquid biopsy results. A table with the measures is shown, according to the contents of the file. In addition to the measures, the user may also associate a set of files with an experiment.